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However, it also retains disadvantages: e.g., possible low adherence due to difficulties related to adhering to a multidrug regimen (more drugs, more doses, to be taken at different times) and higher costs (although long-term cost implications with respect to the gain in disease delay of combination therapy have not yet been carried out, some analyses suggest that initial higher costs may be partially offset by a decrease in T2D-related complications and a delayed insulin starting point) [140]